View abstract. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Fowler on selenium side effects: This is something that must be discussed with the prescribing doctor. View abstract. View abstract. Most research shows that taking selenium supplements does not improve cholesterol levels in people with dyslipidemia. Adverse effects of selenium What are the side effects of selenium? Am.J Clin.Nutr. Selenium deficiency increases the pathology of an influenza virus infection. View abstract. View abstract. Early research shows that taking yeast enriched with selenium seems to decrease how much mercury the body absorbs in Chinese people exposed to high levels of mercury in the environment. View abstract. Selenium for preventing cancer. Vinceti M, Filippini T, Del Giovane C, et al. A., Breckler, L., Hale, J., Lehmann, H., Franklin, P., Lyons, G., Ching, S. Y., Mori, T. A., Barden, A., and Prescott, S. L. Supplementation with vitamins C, E, beta-carotene and selenium has no effect on anti-oxidant status and immune responses in allergic adults: a randomized controlled trial. Ishikawa M, Sasaki M, Koiwai K, et al. Shaheen, S. O., Newson, R. B., Rayman, M. P., Wong, A. P., Tumilty, M. K., Phillips, J. M., Potts, J. F., Kelly, F. J., White, P. T., and Burney, P. G. Randomised, double blind, placebo-controlled trial of selenium supplementation in adult asthma. Mayo Clin.Proc. Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease. Clin Chim Acta 2006;373(1-2):92-98. Digestion 1998;59(2):148-156. Biomed Khim. Last updated on Dec 16, 2019. BMJ 5-14-2005;330(7500):1109. Selenium supply and glutathione peroxidase activity in breastfed Polish infants. Effects of selenium supplementation in the early stage of autoimmune thyroiditis in childhood: an open-label pilot study. View abstract. 2004;(2):CD003538. Van Dael P, Davidsson L, Munoz-Box R, et al. We comply with the HONcode standard for trustworthy health information -, Vitamin/Mineral Supplementation and Deficiency. Groenbaek, K., Friis, H., Hansen, M., Ring-Larsen, H., and Krarup, H. B. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Early research shows that taking 200 mcg of selenium daily for 4 years does not prevent dementia. J Natl Cancer Inst 2006;98:974-83. Selenium, zinc, and copper concentrations in the blood and milk of lactating women. Biochem Pharmacol 1991;41:1429-37. Selenium is a component of more than 30 proteins that have important roles in the body, including reproduction, the production of DNA and thyroid hormones, and protection against cellular damage and infections. Morgia G, Russo G, Voce S, et al. Jamilian M, Mansury S, Bahmani F, Heidar Z, Amirani E, Asemi Z. Crit Care 2006;10(6):R153. Thromb Res 1984;34:389-96. Z.Gesamte Inn.Med 1991;46(5):145-149. It is not known if selenium alone decreases the effectiveness of some medications used for lowering cholesterol. Benton, D. Selenium intake, mood and other aspects of psychological functioning. (Munich) 10-15-1999;94 Suppl 3:45-48. Helzlsouer KJ, Huang HY, Alberg AJ, et al. (check all that apply), What factors are most important to you? View abstract. 3-21-2012;104(6):488-492. #5. Cancer Epidemiol.Biomarkers Prev. View abstract. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Effect of double-blind cross-over selenium supplementation on lipid peroxidation markers in cystic fibrosis patients. Al-Taie, O. H., Seufert, J., Karvar, S., Adolph, C., Mork, H., Scheurlen, M., Kohrle, J., and Jakob, F. Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity in peripheral blood and distal colon mucosa in past and present carriers of colon adenomas. View abstract. View abstract. Gynecol Oncol 2004;93:320-7. Am J Clin Nutr. 1997;31(6):358-361. Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial. Aaseth J, Haugen M, Forre O. Rheumatoid arthritis and metal compounds-perspectives on the role of oxygen radical detoxification. Evans, J. R. and Henshaw, K. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Chatterjee S, Combs GF Jr, Chattopadhyay A, Stolzenberg-Solomon R. Serum selenium and pancreatic cancer: a prospective study in the Prostate, Lung, Colorectal and Ovarian Cancer Trial cohort. View abstract. View abstract. View abstract. N Engl J Med 2001;345:1583-93. Other research shows that taking selenium alone or with other nutrients does not reduce lung cancer risk. Yamaguchi, T., Sano, K., Takakura, K., Saito, I., Shinohara, Y., Asano, T., and Yasuhara, H. Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Klein EA, Thompson IM Jr, Tangen CM, et al. Eur.J Cancer 2004;40(11):1713-1723. View abstract. Br J Nutr 2001;85:517-47.. View abstract. Nutr.Health 2007;19(1-2):85-102. Hype about glucosamine. Duffield AJ, Thomson CD, Hill KE, Williams S. An estimation of selenium requirements for New Zealanders. Greul, A. K., Grundmann, J. U., Heinrich, F., Pfitzner, I., Bernhardt, J., Ambach, A., Biesalski, H. K., and Gollnick, H. Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Medications used for lowering cholesterol (Statins) interacts with SELENIUM. Golik A, Modai D, Averbukh Z, et al. Urinary and fecal excretions and absorption of a large supplement of selenium: superiority of selenate over selenite. Korpela, H., Kumpulainen, J., Jussila, E., Kemila, S., Kaariainen, M., Kaariainen, T., and Sotaniemi, E. A. View abstract. Orv.Hetil. View abstract. There isn't enough information to know if there is an important interaction between birth control pills and selenium. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Clark LC, Combs GF Jr, Turnbull BW, et al. Evidence on the effects of selenium on rheumatoid arthritis is mixed. Kamali A, Amirani E, Asemi Z. View abstract. View abstract. Information from this source is evidence-based and objective, and without commercial influence. Negro, R., Greco, G., Mangieri, T., Pezzarossa, A., Dazzi, D., and Hassan, H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Epidemiol Commun Health 1983;37:213-7. Nat.Clin.Pract Endocrinol.Metab 2008;4(8):454-460. Rao CV, Wang CQ, Simi B, et al. Dietary selenium supplementation prolongs pentobarbital induced hypnosis. 2003;29(5):834-840. Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer. ferrous sulfate, folic acid, ergocalciferol, Zinc, thiamine. 2005;14(7):1596-1607. J Trace Elem.Med Biol. Reduction of nosocomial pneumonia after major burns by trace element supplementation: aggregation of two randomised trials. A clinical review of micronutrients in HIV infection. Gomm, S. A., Thatcher, N., Cuthbert, A., Chang, J., Burmester, H., Hall, P., and Carroll, K. B. Effect of Selenium Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis. Biol Trace Elem Res. There are no effects of drug abuse with the use of selenium. Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., and Gluud, C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. In people who already have heart disease, taking 100 mcg of selenium in combination with beta-carotene, vitamin C, and vitamin E does not seem to prevent the condition from becoming worse. Long term use of high selenium doses can lead to dangerous side effects. The effect of selenium therapy on autoimmune thyroiditis. Burney, P., Potts, J., Makowska, J., Kowalski, M., Phillips, J., Gnatiuc, L., Shaheen, S., Joos, G., Van, Cauwenberge P., van, Zele T., Verbruggen, K., van, Durme Y., Derudder, I., Wohrl, S., Godnic-Cvar, J., Salameh, B., Skadhauge, L., Thomsen, G., Zuberbier, T., Bergmann, K. C., Heinzerling, L., Renz, H., Al-Fakhri, N., Kosche, B., Hildenberg, A., Papadopoulos, N. G., Xepapadaki, P., Zannikos, K., Gjomarkaj, M., Bruno, A., Pace, E., Bonini, S., Bresciani, M., Gramiccioni, C., Fokkens, W., Weersink, E. J., Carlsen, K. H., Bakkeheim, E., Loureiro, C., Villanueva, C. M., Sanjuas, C., Zock, J. P., Lundback, B., and Janson, C. A case-control study of the relation between plasma selenium and asthma in European populations: a GAL2EN project. View abstract. View abstract. Written by Owen Bond . King JC. Cancer Epidemiol Biomarkers Prev 2000;9:883-7.. View abstract. 2003;(4):CD003312. J Intern.Med 1990;228(6):577-581. View abstract. Clin Infect Dis 1996;23:654-6. Colon cancer, rectal cancer. Some of these enzymes are involved in specific pathways in your body that can prevent cell damage (usually by interacting with harmful molecules known as … View abstract. Rheumatoid arthritis (RA). Selenium in the treatment of autoimmune thyroiditis. Ups J Med Sci 1977;82:39-41. Selenium is a mineral that's essential to the body in trace amounts, mainly for synthesizing enzymes, but it can be toxic in large amounts. The two faces of selenium-deficiency and toxicity--are similar in animals and man. Effects of dietary selenium on sperm motility in healthy men. Hiramatsu T, Imoto M, Koyano T, Umezawa K. Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia. Proceedings of International Selenium Tellurium Development Association 1998;91-94. PLoS One. View abstract. Selenium supplementation in the treatment of Hashimoto's thyroiditis: A systematic review and a meta-analysis. Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial. 2009;134(3):83-86. Ketogenic diet: Rapid onset of selenium deficiency-induced cardiac decompensation. View abstract. Selenium is an essential trace element and is involved in antioxidant protection and redox-regulation in humans. Kelly P, Musonda R, Kafwembe E, et al. Some evidence shows that taking selenium daily for up to 2 years can slow how quickly HIV spreads and can increase immune function. View abstract. Wallace, K., Byers, T., Morris, J. S., Cole, B. F., Greenberg, E. R., Baron, J. Dunstan, J. Horm Metab Res. View abstract. Early research showed that taking 200 mcg if selenium daily reduced the risk of lunch cancer by about 46% in people without selenium deficiency. Cochrane Database Syst Rev 2013;1:CD009671. Biosci Rep. 2016;36(5). Pan, S. Y., Ugnat, A. M., Mao, Y., Wen, S. W., and Johnson, K. C. A case-control study of diet and the risk of ovarian cancer. Farrokhian A, Bahmani F, Taghizadeh M, et al. Am J Clin Nutr 2008;87:370-8. Clark LC, Dalkin B, Krongrad A, et al. View abstract. Gamstorp, I., Gustavson, K. H., Hellstrom, O., and Nordgren, B. View abstract. View abstract. Vernie LN, de Goeij JJ, Zegers C, et al. A prospective randomized blind trial]. View abstract. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Rayman, M. P. The use of high-selenium yeast to raise selenium status: how does it measure up? Selenium supplementation for sepsis: A meta-analysis of randomized controlled trials. Olsen, A., Thiong'o, F. W., Ouma, J. H., Mwaniki, D., Magnussen, P., Michaelsen, K. F., Friis, H., and Geissler, P. W. Effects of multimicronutrient supplementation on helminth reinfection: a randomized, controlled trial in Kenyan schoolchildren. J Androl 2009;30(5):525-533. Research shows that taking up to 200 mcg of selenium daily along with thyroid, A disorder that affects the bones and joints, usually in people with selenium deficiency (Kashin-Beck disease). A double-blind randomized trial. View abstract. There are no known side effects associated with Selenium when it is consumed in normal doses. A., Dean, J. M., Holubkov, R., Berger, J., Meert, K. L., Anand, K. J., Zimmerman, J., Newth, C. J., Harrison, R., Burr, J., Willson, D. F., and Nicholson, C. The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial. 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